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Dernières publications
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Medhi Hassani, Dylan Moutachi, Mégane Lemaitre, Alexis Boulinguiez, Denis Furling, et al.. Beneficial effects of resistance training on both mild and severe mouse dystrophic muscle function as a preclinical option for Duchenne muscular dystrophy. PLoS ONE, 2024, 19, ⟨10.1371/journal.pone.0295700⟩. ⟨hal-04501283⟩
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Florent Porquet, Lin Weidong, Kévin Jehasse, Hélène Gazon, Maria Kondili, et al.. Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy - Nucleic Acids, 2023, 32, pp.857 - 871. ⟨10.1016/j.omtn.2023.05.007⟩. ⟨hal-04287597⟩
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Caroline Le Guiner, T Larcher, A Lafoux, G Toumaniantz, S Webb, et al.. Characterization of the muscular and cardiac diseases of the DMSXL mouse model, a transgenic mouse model for Myotonic Dystrophy type 1. American Society of Gene & Cell Therapy, May 2023, LOS ANGELES, United States. ⟨hal-04096181⟩
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Dylan Moutachi, Mégane Lemaitre, Clément Delacroix, Onnik Agbulut, Denis Furling, et al.. Valproic acid reduces muscle susceptibility to contraction‐induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. Clinical and Experimental Pharmacology and Physiology, In press, ⟨10.1111/1440-1681.13804⟩. ⟨hal-04146953⟩
Chiffres clés
132
Publications avec texte intégral
Open Access
52 %
Mots clés
Dilated cardiomyopathy
Cell culture model
Dynamin 2
PCR
Myotonic dystrophy
BIOLOGIE MOLECULAIRE
Myostatin
Mouse model
Muscle
Astrocyte
In vivo
Oligodendrocyte
Intermediate filament
Transcriptomics
Humans
Acute coronary syndrome
Male
MBNL
Aging
CMS
Acetylcholinesterase deficiency
KNOCKOUT MICE
Dystrophie myotonique
CTG repeat contractions
Antisense oligonucleotides
Transgenic mouse
Lc3
Myotonic dystrophy type 1
Myelin
Cell model
Alternative splicing
Muscular dystrophy
Transgenic mouse model
CRISPR/Cas9
Oligodendrocytes
Brain
ARN
Motoneuron
CTG repeats
Knockout
Thérapie génique
Animals
Glucocorticoid-receptor
Genotype phenotype correlation
RNA interference
Gene therapy
RNA biology
CONGENITAL MYATHENIC SYNDROME
ACETYLCHOLINESTERASE
Long read sequencing
CRISPRi
Myotonic dystrophy mouse models
Hypoxia
Autophagy
DMSXL mice
Duchenne muscular dystrophy
Cytoskeleton
Central nervous system
Brain dysfunction
Trinucleotide Repeat Expansion
GSK3
Gene Therapy
Heart failure
Cell penetrating peptide
DM1
Quantitative microdialysis
Cardiac muscle
Maximal force
Glutamate
Trinucleotide repeat expansion
Antisense oligonucleotide
Glial cells
Diaphragm
Exercise
Dystrophin
Desmin
Gene editing
GABA
Skeletal muscle
Exercice
Therapy
DMPK
Mice
Myotonic Dystrophy
Myotonic Dystrophy Type 1
Fibrosis
Neuron
Acetylcholinesterase knockout mouse
Myotonic Dystrophy type 1
RNA splicing
Mouse models
Centronuclear myopathy
Dystrophie Myotonique
PacBio
Heart
Expression
CTG repeat instability
AAV
Astrocytes
Glucocorticoids