Article Dans Une Revue Vaccine Année : 2025

Timing of rejection events preceded by Covid-19 mRNA vaccination in recipients of solid organ transplants

Johan Noble
  • Fonction : Auteur
Agnès Bonadona
  • Fonction : Auteur
Caroline Augier
  • Fonction : Auteur
Thomas Jouve
  • Fonction : Auteur
Aude Boignard
  • Fonction : Auteur
Loïc Falque
  • Fonction : Auteur
Salomé Gallet
  • Fonction : Auteur
Pierrick Bedouch
  • Fonction : Auteur
Lionel Rostaing
  • Fonction : Auteur
Olivier Epaulard
  • Fonction : Auteur
  • PersonId : 1199205

Résumé

Objectives: SARS-CoV-2 mRNA vaccine reactogenicity has raised concerns regarding the risk of rejection in solid organ transplant recipients. We explored whether SOT recipients diagnosed with acute rejection had previously received a vaccine injection within a timeframe consistent with a causal link. Methods: We identified all SOT recipients with a diagnosis of acute rejection from 2020 to 2022 and who had previously received a SARS-CoV-2 vaccination, and analysed whether the delay between vaccination and rejection was constant. Results: In the 45 identified patients, median delay between the last SARS-CoV-2 vaccination and the rejection was 102 days [IQR 48-178]; the continuous distribution of this delay, with no identifiable time pattern, is not in favor of a role of vaccination in rejection. Conclusion: SARS-CoV-2 mRNA vaccination is unlikely to trigger rejection in SOT recipients.

Fichier principal
Vignette du fichier
Timing of rejection events preceded by Covid-19 ....pdf (386) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
licence

Dates et versions

hal-04921720 , version 1 (30-01-2025)

Licence

Identifiants

Citer

Quentin Perrier, Johan Noble, Agnès Bonadona, Caroline Augier, Thomas Jouve, et al.. Timing of rejection events preceded by Covid-19 mRNA vaccination in recipients of solid organ transplants. Vaccine, 2025, 45, pp.126617. ⟨10.1016/j.vaccine.2024.126617⟩. ⟨hal-04921720⟩

Collections

UGA LBFA
0 Consultations
0 Téléchargements

Altmetric

Partager

More